Triclosan's Antagonism of Thyroxine and T3: Wilson's Syndrome?

Structural considerations and the following abstract raise concerns about Triclosan interfering with thyroid hormone metabolism in the body, thereby lowering body temperature, and producing a variety of metabolic imbalances associated with poor thyroid hormone utilization. Wilson's Syndrome, supposedly a new thyroid disorder, could very well have environmental causes.

THYROXINE--Thyroid Hormone

     TRICLOSAN--Antibacterial added to soaps, dishwashing liquids, toothpastes, etc.

ACTIVATED THYROXINE or T3 (3,5,3'-Triiodothyronine)

The acute toxicity of penta-, hexa-, and heptachlorohydroxydiphenyl ethers in mice.

Miller TL, Lorusso DJ, Walsh ML, Deinzer ML

The acute intraperitoneal LD50 values of various hydroxychlorodiphenyl ethers (HO-ClX-DPEs; X = 5-7) in mice have been determined. The acute toxicities observed were on the order of, or slightly less than, that observed previously for 2-hydroxy-2',4,4'-trichlorodiphenyl ether (2-HO-Cl3-DPE; Irgasan DP-300; Triclosan), a commonly used bactericide. However, the acute toxicities determined for these compounds were substantially less than have been observed for HO-Cl9-DPEs and pentachlorophenol. The HO-ClX-DPEs HAD A MARKED HYPOTHERMIC EFFECT, similar to that produced by 2-HO-Cl3-DPE. Symptomatology following exposure to the HO-ClX-DPEs (X = 5-7) suggested a NONSPECIFIC DEPRESSANT EFFECT on the central nervous system.

PMID: 6655733, UI: 84090302

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