Histamine 2 Blockers. Zantac 75, 150, 300 Pepcid 10, 20, 40 Tagament Axid Histamine 2 blockers (H2 Blockers) are used for dyspepsia and for allergic reactions. These products cut the production of stomach acids. For different people different H2 blockers work better. Pepcid seems to be the most effective, however, for different people, different products may or may not be more effective. It takes around 1 hour to work.