Copyright © 1996, 1997, 1998, 1999, 2000, 2001 by Galen Daryl Knight and VitaleTherapeutics, Inc.

Environmental Factors Affecting the 
VitaleTheine Modulator/Monooxygenase System


It has been determined that a variety of toxins probably poison the ability of the vitaletheine modulators to prevent and treat cancer. Most notably among these toxins are the dead cancer cells , themselves, that with conventional chemotherapy and radiation are killed and left in situ to be readsorbed, which releases the carcinogenic substances that caused the cancer in the first place to produce "metastases" and new cancers elsewhere. When the cancer cells die, and in the process rupture and lose their intracellular antioxidants, the membrane fragments resulting oxidize according to reaction #3., supra, and also poison the very vitaletheine modulator-dependent (VSH) immune system that would normally have prevented and treated the cancer. This is graphically illustrated by the following figure in which the therapeutic response to Vitalethine (open squares) is attenuated by the coadministration of dead cancer cells (filled circles):

Note that the extrapolated efficacy in the presence of dead cancer cells drops from about 80% survival to only about 40% survival with the coadministration of only a tiny bolus of attenuated tumor cells. From this data, one can crudely extrapolate (dotted line) a completely effective therapeutic window for vitalethine as being about 10 fg/kg or less, a situation that would reflect a theoretical complete abscence of environmental toxins and dead cancer cells. Since this amount of vitalethine is flanked on either side by the amounts of plutonium and aflatoxin that cause cancer, this is the range of vitalethine concentrations thought to be produced, naturally, when the body is well-nourished and free of environmental toxins.

This theory is supported by the recent finding that a completely pure preparation of the monooxygenase enzyme thought to regulate cholesterol biosynthesis and cancer gene (oncogene) expression, and probably most other biochemical pathways in the body, has a molecule on it that is the same size (M+=383) as vitalethine. This enzyme indirectly catalyzes the oxidation of cysteine residues in proteins and peptides to disulfides, and mixed disulfides with other small molecular weight thiols, providing a vast array of modulation for the various biochemical pathways in the body.

Thus, the insights gained in the discovery of the vitaletheine modulators set the stage for exciting new developments in the fields of environmental toxicology and nutrition for the prevention and treatment of a variety of supposedly intractable and incurable diseases, such as cancer and heart disease.

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